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《Journal of Xuzhou Medical University》 2019-06
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Clinical significance of galectin-3,neutrophil count and neutrophil-to-lymphocyte ratio in non-small cell lung cancer

ZHANG Shuting;GAO Chao;Graduate School,Xuzhou Medical University;Department of Medical Oncology,the Affiliated Hospital of Xuzhou Medical University;  
Objective To investigate the clinical significance of serum galectin-3(Gal-3),neutrophil count(NE)and neutrophil-to-lymphocyte ratio(NLR)in non-small cell lung cancer(NSCLC).Methods A total of 45 newly diagnosed NSCLC patients were selected as research group and 28 healthy subjects were selected as control group.The clinical significance of Gal-3,NE and NLR was analyzed according to the relevant clinicopatholiogical features in NSCLC.Results Gal-3, NE and NLR in the research group were higher than those in the control group(P0.05).Gal-3,NE and NLR were correlated with lymph node metastasis and TNM staging(P0.05),but not with age,pathological type and distant metastasis(P0.05).Single and combined detection of Gal-3,NE and NLR had certain significance in the diagnosis of NSCLC(P0.05).Conclusions Gal-3,NE and NLR may be related to TNM staging,development,invasion,metastasis and prognosis of NSCLC,which is of certain significance for early diagnosis and prognosis of NSCLC.
【Fund】: 江苏省卫生厅课题(2012103006)
【CateGory Index】: R734.2
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