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《Journal of Xuzhou Medical University》 2019-06
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Analysis of clinical factors on nedaplatin-induced anemia in patients with non-small cell lung cancer

WU Rumeng;LIU Yuan;HE Weiping;TANG Yafei;DU Xiuping;WANG Yan;Department of Pharmacy,the Affiliated Hospital of Xuzhou Medical University;Department of Pharmacy,Xuzhou Maternity and Child Health Care Hospital Affiliated to Xuzhou Medical University;Department of Oncology,the Affiliated Hospital of Xuzhou Medical University;  
Objective To analyze the clinical influencing factors of anemia in patients with non-small cell lung cancer(NSCLC)after nedaplatin chemotherapy,and to provide theoretical basis for the safe use of nedaplatin.Methods A total of 124 NSCLC patients who received nedaplatin chemotherapy in the Affiliated Hospital of Xuzhou Medical University were selected.The incidence of anemia in patients with different age,sex,pathological type and stage after chemotherapy was analyzed.Results The incidence of anemia in 124 patients was 70.16%.The incidence of anemia in patients65 years was significantly higher than that in patients ≤65 years(84.85% vs.64.84%,P0.05).The incidence of anemia in squamous cell carcinoma patients was significantly higher than that in adenocarcinoma patients(76.47% vs.53.85%,P0.05).The incidence of anemia in smokers was significantly higher than that in nonsmokers(76.19% vs.57.50%,P0.05).Conclusions The incidence of anemia in elderly,squamous cell carcinoma and smoking patients is high after receiving nedaplatin chemotherapy in NSCLC patients.Anemia should be prevented before taking nedaplatin regimen.
【Fund】: 江苏省卫生厅国际支撑计划(JSH-2011-035);; 江苏省药学会-奥赛康临床药学基金科研项目(A201823)
【CateGory Index】: R734.2;R556
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